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This study also showed a non-significant 17% reduction in albuminuria.67 The AWARD-7 study analyzed the efficacy of dulaglutide in patients with DM2 and moderate-severe CKD (mean eGFR 38 ml/min/1.73 m2)
Conversely, those exploring switching between treatments should understand the conversion charts and dose equivalence guides to manage transitions safely
In HEK293 cells expressing human GIP receptor or GLP-1 receptor, tirzepatide potently stimulated cAMP accumulation by both receptors, and the potency of tirzepatide was similar to that of native GIP and approximately 13-fold weaker than that of GLP-1 in these assays [88]
Everything in Protocol 1, plus: Protein supplement: Increase to 1.6-2.0 g/kg total daily protein (likely requires 40-80 grams from supplements) Creatine monohydrate: 5 grams daily HMB: 3 grams daily Omega-3 fish oil: 1-2 grams EPA/DHA daily Expected benefits: Significantly reduced lean mass loss, maintained or improved strength, better metabolic rate preservation, improved body composition outcomes
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