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In ME/CFS patients, the scarcity of butyrate-producing bacteria could be due to low levels of SCFA, potentially causing post-exertional malaise and a cycle of inactivity

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What is supported in animal models Increased lipolysis, increased fat oxidation, decreased lipogenesis, no apparent effect on plasma glucose or insulin sensitivity, and signal that intact beta-3 adrenergic receptor activity matters for the fat-loss effect

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