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During the first few weeks, most protocols involve a lower starting dose to let the body adjust, and noticeable weight changes during this period are typically modest

Most rebound occurs within 3-6 months, with hunger hormones (especially ghrelin) rising significantly within 2-4 weeks of stopping

5 The fact that this effect was observed at nanomolar concentrations is pharmacologically noteworthy: it suggests receptor-level affinity rather than non-specific stimulatory effects