A: Hyaluronic acid hydrates and lubricates
To stop vitiligo progression and promote a favorable environment for repigmentation (maturation of melanocytes), is necessary an intervention that reduces ROS production, improves the EAS, and reduces the pro-inflammatory profile ( Origin of Oxidative Stress and Vulnerable Antioxidant System: Mechanistic Factors in Vitiligo Development It is well known in vitiligo patients that dramatic imbalance between the oxidant system (high) and EAS (deficient) leads to a predominant state of OS (Figure 2, the magnitude of ROS production in melanocytes in vitiligo patients is due to a high electrical potential in mitochondrial intermembrane space ( Figure 1A) suggests that ROS production (with the extra oxygen consumption) over to ATP production (as illustrated in Figure 2), as discussed in this paper, is a profile to activating cell apoptosis in epidermal from vitiligo patients

Apoptosis is mediated by cysteine protease family caspases, which are divided into the endogenous apoptosis pathway and exogenous apoptosis pathway [15, 16]
[DOI] [PubMed] [Google Scholar] 428.Polzikov M., Blinov D., Barakhoeva Z., Vovk L., Fetisova Y., Ovchinnikova M., Tischenko M., Zorina I., Yurasov V., Ushakova T., et al