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GLP-1R mRNA and GLP-1 immunoreactivity was detected in the VTA and NAc, as well as other reward associated areas including lateral hypothalamus, lateral habenula, hippocampus, and substantia nigra (Merchenthaler et al., Afferent and efferent innervation of the hindbrain GLP-1-producing neurons Unlike many of its gut or fat hormone counterparts (ghrelin or leptin) for which there is little evidence of central production, GLP-1 can be made in the brain

Current evidence is limited but suggests that interaction risks are manageable with proper baseline assessment and ongoing monitoring of hormone levels and metabolic markers

This often happens due to a chemical pregnancy, where fertilization occurs but the pregnancy ends very early before the embryo develops

20, 2026 JAMA, Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity, Jan