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In particular, the multiple metabolic actions of glucagon highlight the importance of understanding the contributions of individual hormone action to inform the safe, effective and tailored use of GLP-1/glucagon co-agonists to target weight loss and metabolic disease in the future

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18 While we must be guarded in concluding that it is the most effective without a head-to-head trial, it is nevertheless noteworthy

John Eng at the VA Medical Center in the Bronx discovered exendin-4, a peptide in Gila monster venom that mimicked GLP-1 but lasted hours instead of minutes