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Quick Answer: Tirzepatide does not directly cause gallstones, but its rapid weight loss effects increase gallstone risk, with clinical trials showing cholelithiasis in 2.5% of treated patients versus 1.0% on placebo

It offers intensive therapeutic effects, including a powerful immune boost, addressing chronic infections, oxidative stress, and systemic inflammation

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KaplanMeier curves representing our as-treated analysis of GLP1 receptor agonists versus SGLT2 inhibitors implied that long-term continuous SGLT2 inhibitor use might be associated with greater benefit