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It's important to note that clinically significant hypoglycemia is uncommon with GLP-1 receptor agonists unless they are used in combination with insulin or sulfonylureas

A series of transporters primarily acting in the kidney is responsible for the control of UA in the blood 3 , with URAT1 (coded by SLC22A12) responsible for most kidney reabsorption into the blood and ABCG2 (or breast cancer resistance protein, BCRP) mainly involved in secretion into urine

Cytochrome P450 monooxygenase CYP1A1 induction by maternal cigarette smoking or drug abuse has been convincingly demonstrated in several studies [122,123]

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