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17beta-Estradiol Reduces Demyelination in Cuprizone-Fed Mice by Promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome

Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure

Reduced Inflammation : It helps to decrease inflammation, which can be beneficial for chronic conditions such as arthritis

General recommendations are for 2.4 micrograms (mcg) a day, although those who are elderly or breastfeeding women may need more