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Oncol Rep 2014

Nausea (53.3% of patients), diarrhea (34.9%) and vomiting (30.3%) being a few of the most common

You can compare this to cyanocobalamin which requires extra steps to be used by the body assuming it actually makes it into the body through the gut

47 They found that when drugs are administered intranasally, the use of nanoformulations significantly increases DTE and DTP values compared to when drugs are in solution form, demonstrating the advantages of nanoformulations in intranasal administration