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Alanine aminotransferase (ALT) (42.7 33.6 mmol/L vs 28.1 40.0 mmol/L, P = 0.008) and aspartate aminotransferase (AST) (30.1 23.9 mmol/L vs 21.1 10.4 mmol/L, P = 0.002) levels after monotherapy were significantly lowered compared to those at baseline (Table 1)

GSK3 is an essential enzyme that exerts an inhibitory effect on the canonical Wnt/-catenin signaling pathway