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476 Oligodendrocyte differentiation and myelination are impaired by mtDNA damage and oxidative stress, leading to altered transcription, double-strand breaks, and mitochondrial deletion events, especially involving complex IV

Upper tolerable limits have not been established, but doses above 1,000 mg per day may increase the risk of gastrointestinal discomfort

Haufe S, Engeli S, Kast P, Bhnke J, Utz W, Haas V, et al

In animal and emerging human data, it upregulates VEGF (vascular endothelial growth factor) and FGF (fibroblast growth factor) to spark angiogenesis the creation of new blood vessels critical for healing