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2.1 Diabetes Firstly, type 2 diabetes is closely related to obesity and diet

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Studies have shown that cisplatin induces CAFs to secrete chemokine (CC motif) ligand 5 (CCL5), which inhibits cisplatin-induced tumor cell apoptosis by regulating the STAT3 and PI3K/Akt signaling pathways, thereby further promoting tumor cell resistance to cisplatin treatment [42]

In this regard, Lynch et al[51] has shown that systemic IGF-I treatment improved the functional properties of skeletal muscles from 129P1 ReJ-Lama2 dy dystrophic mice, a mouse model for congenital muscular dystrophy